SIRT7 in Aging Biology: Nucleolar Deacetylase Activity, Ribosomal Homeostasis, and Genomic Stability in the Context of Cellular Senescence

Key Points

• This review explores SIRT7's molecular mechanisms related to aging, focusing on its role in nucleolar deacetylase activity and genomic stability.
• Review of existing literature across in vitro, rodent, and human model systems.
• Analysis of SIRT7's nucleolar functions and implications in ribosomal DNA stabilization.
• SIRT7 contributes to genomic stability by maintaining ribosomal DNA integrity.
• Evidence shows varying confidence levels in SIRT7's role depending on the model system used.