Base- Mediated 2+4 Annulation of Benzothiazolium Salts and 2-Aminobenzaldehydes: Selective Synthesis of 2-Amino and 2-Thio- Substituted Quinolines

Key Points

• To develop a new synthetic method for 2-amino and 2-thio-substituted quinolines.
• Transition-metal-free [2+4] cyclization of benzothiazolium salts with 2-aminobenzaldehydes.
• Control of chemoselectivity during the reaction.
• Successfully synthesized N-substituted and S-substituted quinoline derivatives.
• Demonstrated significance in chemoselectivity for quinoline formation.