EtCBN-associated olfactory dysfunction involves Irf7 signaling and a microbiota-metabolite axis.

Key Points

• This study investigates the relationship between EtCBN, Irf7 signaling, and olfactory dysfunction.
• Examined the interaction between EtCBN and Irf7 signaling pathways.
• Explored the microbiota-metabolite axis in relation to neurotoxicity.
• Findings indicate a connection between EtCBN-Irf7 interaction and olfactory dysfunction.
• Proposed adverse outcome pathway may provide new insights into therapeutic targets.