What question did this study set out to answer?

The aim is to explore the utility of α-halodicyclopentadienones in creating new fused heterocycles.

May 3, 2026Organic & Biomolecular Chemistry0 citations

Utility of α-halodicyclopentadienones for the synthesis of novel fused heterocycles

SLSohan LalIndian Institute of Technology Bombay GTGangavara L. TejashreeIndian Institute of Technology Bombay DDDipankar DasCentral Salt and Marine Chemicals Research Institute

Key Points

The aim is to explore the utility of α-halodicyclopentadienones in creating new fused heterocycles.
Base-mediated Michael addition of amidines to α-halodicyclopentadienones
Cyclization of intermediate Michael adducts to form fused tetracycles and hexacycles
Assessment of diastereoselectivity in cyclization products.
Produced linear fused tetracycles to hexacycles
Achieved complete diastereoselectivity in the reaction outcome.

Abstract

Base-mediated Michael addition of amidines, oxindoles and thio-oxindoles to α-halodicyclopentadienones (halo-DCPD-enones) followed by cyclization of the intermediate Michael adducts leads to linear fused tetracycles to hexacycles with complete diastereoselectivity. While...

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Cite This Study

Lal et al. (Wed,) studied this question.

synapsesocial.com/papers/69f6e6968071d4f1bdfc73c9 https://doi.org/https://doi.org/10.1039/d6ob00317f

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