Engineering Coumarin‐Based Afterglow Luminescence Probes for Activatable Imaging Peroxynitrite In Vivo

Key Points

• This research focuses on developing a novel imaging probe for detecting peroxynitrite in living organisms.
• Engineered coumarin-based luminescence probes
• Induction of afterglow emission through singlet oxygen production
• Evaluation of imaging capabilities in ulcerative colitis and Parkinson's disease models.
• The probes exhibited high activation contrast and reduced autofluorescence
• Demonstrated efficacy in assessing therapeutic responses in both ulcerative colitis and Parkinson's disease.