Biotransformation of progesterone by Aspergillus welwitschiae CCMB 674 yields a novel metabolite 11α,21-dihydroxyprogesterone, alongside three known compounds

Key Points

• The research focuses on the biotransformation of progesterone by Aspergillus welwitschiae.
• The biotransformation process was conducted over 168 hours.
• The study analyzed the yield of a novel metabolite and three known compounds.
• A novel metabolite, 11α,21-dihydroxyprogesterone, was produced.
• Aspergillus welwitschiae showed potential as a biocatalyst for selective steroid hydroxylation.