From Food Additives to Neurodegeneration: The Emerging Role of Polyphosphates in Tauopathies

Key Points

• To explore the impact of polyphosphates on tau aggregation and mitochondrial dysfunction in tauopathies.
• Investigated the role of endogenous polyphosphates in tau aggregation.
• Examined mitochondrial dysfunction associated with tauopathies.
• Assessed the effects of dietary exogenous polyphosphates from processed foods.
• Found that exogenous polyphosphates may facilitate neurodegeneration.
• Demonstrated a link between dietary components and tau aggregation.
• Identified mitochondrial dysfunction as a potential outcome of polyphosphate exposure.