Electrochemical Site-Selective C(sp3 )-H Heteroarylation of Proline-Containing Peptides

Key Points

• The aim is to develop a method for the site-selective modification of C(sp3)-H bonds in peptides to enhance peptide-based therapeutics.
• Utilized electrochemical approaches to facilitate C(sp3)-H heteroarylation.
• Focused on proline-containing peptides as targets for modification.
• Employed transition-metal catalysts for the reaction process.
• Achieved significant site-selectivity in C(sp3)-H modification of proline peptides.
• Demonstrated improved yield and reaction efficiency compared to traditional methods.
• Provided foundational insights for further applications in peptide therapeutics.