Randomized trial demonstrates site-selective C(sp3)-H modification in proline-containing peptides, highlighting advancements in peptide therapeutics.
The site-selective modification of aliphatic C(sp 3 )-H bonds within peptides represents a significant synthetic challenge, crucial for advancing peptide-based therapeutics. Current strategies largely depend on transition-metal catalysts, directing groups...
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Liu et al. (2026) studied this question.
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