Site-Selective α-C(sp 3 )-H Bond Functionalization of Amines/Amides via 1,2-Hydrogen Atom Transfer

Dong Zou; Jiaqi Yao

doi:10.1039/d6qo00382f

January 1, 2026Organic Chemistry Frontiers

Site-Selective α-C(sp 3 )-H Bond Functionalization of Amines/Amides via 1,2-Hydrogen Atom Transfer

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Key Points

The research focuses on improving site-selective functionalization of C(sp3)-H bonds in organic synthesis.
Utilized nitrogen-centered radical-mediated 1,2-hydrogen atom transfer strategy.
Explored functionalization techniques for amines and amides.
Assessed reaction efficiency and selectivity in C(sp3)-H bond modification.
Established a new pathway for site-selective functionalization of C(sp3)-H bonds.
Demonstrated effectiveness of radical-mediated hydrogen atom transfer for amines and amides.

Implication

Research reveals 1,2-hydrogen atom transfer improves site-selective functionalization in amines and amides, highlighting advancements in organic synthesis.

Abstract

Site-selective functionalization of C(sp 3 )-H bond represents a core challenge in modern organic synthesis. The strategy of nitrogen-centered radical-mediated 1,2-hydrogen atom transfer (1,2-HAT) provides an efficient new pathway for...

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Cite This Study

Zou et al. (2026) studied this question.

synapsesocial.com/papers/69f15432879cb923c49446c0 https://doi.org/10.1039/d6qo00382f

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Site-Selective α-C(sp 3 )-H Bond Functionalization of Amines/Amides via 1,2-Hydrogen Atom Transfer

Key Points

Implication

Abstract

Discussion

Cite This Study

Site-Selective α-C(sp 3 )-H Bond Functionalization of Amines/Amides via 1,2-Hydrogen Atom Transfer

Key Points

Implication

Abstract

Discussion

Cite This Study

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