What question did this study set out to answer?

This research aims to explore the role of ERα in dendritic cells and its effect on antigen cross-presentation and T cell immunity.

May 8, 2026Nature Communications0 citationsOpen Access

ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8+ T cell immunity

YLYaxin LiuChinese Academy of Medical Sciences & Peking Union Medical College ZMZhongfei MaChinese Academy of Medical Sciences & Peking Union Medical College XLXuelian LiChinese Academy of Medical Sciences & Peking Union Medical College

Key Points

This research aims to explore the role of ERα in dendritic cells and its effect on antigen cross-presentation and T cell immunity.
Investigated the function of ERα in dendritic cells
Analyzed phagosome integrity involved in antigen processing
Evaluated CD8+ T cell responses to ERα blockade
ERα blockade improves antigen cross-presentation in dendritic cells
Enhanced CD8+ T cell immunity observed
Identified phagosome integrity as a critical checkpoint for antigen processing

Abstract

T cells. Our work thus uncovers a non-canonical role of ERα in phagosome integrity as a checkpoint for antigen cross-presentation in DCs, and implicates ERα-targeted DC vaccines as a potential immunotherapeutic strategy.

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Cite This Study

Liu et al. (Tue,) studied this question.

synapsesocial.com/papers/69fd7ddcbfa21ec5bbf0619d https://doi.org/https://doi.org/10.1038/s41467-026-72647-7

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