What question did this study set out to answer?

This review aims to highlight the recent advancements in CRBN-recruiting molecular glue degraders and their implications for medicinal chemistry.

May 10, 2026

Front Cover: Synthetic and Medicinal Chemistry Perspectives on Cereblon‐Binding Molecular Glue Degraders: Recent Advances and Emerging Trends (Eur. J. Org. Chem. 17/2026)

Key Points

This review aims to highlight the recent advancements in CRBN-recruiting molecular glue degraders and their implications for medicinal chemistry.
Discussed recent advancements since 2023 in CRBN-recruiting molecular glue degraders.
Illustrated shift from canonical to non-canonical chemotypes.
Explained the role of AI-enabled modeling in accelerating the discovery process.
Identified new ligand-specific features that influence the CRBN–ligand–neosubstrate interface.
Demonstrated the expansion of neosubstrate space through recent discoveries.
Highlighted the potential impact of AI in facilitating the discovery of atypical molecular glue degraders.

Abstract

The Front Cover highlights advances in CRBN-recruiting molecular glue degraders since 2023, illustrating the shift from canonical glues to non-canonical chemotypes that expand the neosubstrate space. A glutarimide anchor binds to CRBN, while ligand-specific features shape the CRBN–ligand–neosubstrate interface. AI-enabled modeling can further accelerate the discovery of atypical MGDs. More information can be found in the Review by N.-J. Kim and co-workers (DOI: 10.1002/ejoc.202501208). Created in BioRender: Won, H.-J. (2026) https://BioRender.com/x39o4mt.

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Cite This Study

Won et al. (Tue,) studied this question.

synapsesocial.com/papers/6a00217ac8f74e3340f9c59d https://doi.org/https://doi.org/10.1002/ejoc.70512

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