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value of 0.8647. We also confirmed that the model gives high attention to drug-target genes and cancer-related pathways when predicting a response. The validity of predicted results was proven by in vitro cytotoxicity assay. Overall, we propose that our hierarchical and interpretable AI-based model is capable of interpreting intrinsic characteristics of cancer cells and drugs for accurate prediction of cancer-drug responses.
Jin et al. (Tue,) studied this question.