Click chemistry of phenyl 1,2,3-triazole–2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies

Key Points

• This research aims to synthesize and evaluate novel phenyl triazole-pyridylpiperazine derivatives for their anticancer effects.
• Synthesis of phenyl triazole-pyridylpiperazine derivatives
• Testing against cancer cells
• Molecular modeling and computational studies to predict activity
• Compounds 15 and 18 showed potent anticancer activity comparable to doxorubicin
• Favorable ADME profiles noted for the compounds
• Stable binding to EGFR was observed