BACKGROUND: Agaricus bisporus contains bioactive proteins, including tyrosinase, which may influence dopaminergic metabolism. Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons driven by oxidative stress, neuroinflammation, and apoptosis. OBJECTIVE: To evaluate the neuroprotective effects of an Agaricus bisporus protein extract (ABE) and its mechanistic basis in an MPTP-induced mouse model of PD. METHODS: A tyrosinase-enriched protein fraction was isolated and administered orally to MPTP-treated mice for 20 days. Behavioral performance, dopaminergic markers, oxidative stress parameters, inflammatory mediators, and apoptosis-related proteins were assessed in the substantia nigra. RESULTS: < 0.001). CONCLUSION: ABE exerts neuroprotective effects in MPTP-induced PD via tyrosinase-associated enhancement of dopaminergic metabolism, alongside antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Zhgenti et al. (Thu,) studied this question.