Graded compression stockings (0%), heparin (2.6%), and aspirin (5.7%) significantly reduced DVT compared to control (26.1%) in high-risk pulmonary patients, whereas elastic bandages did not.
Cohort (n=192)
Do graded compression stockings, elastic bandages, heparin, or aspirin prevent deep venous thrombosis in high-risk pulmonary patients on bed rest?
Graded compression stockings, subcutaneous heparin, and oral aspirin significantly reduced the incidence of DVT compared to control in high-risk pulmonary patients on bed rest, whereas elastic bandages did not.
Absolute Event Rate: 0% vs 26.1%
p-value: p=<0.0003
Information is lacking about the prevalence of, and the best method of preventing deep venous thrombosis (DVT) of the lower extremities in patients forty years or older with pulmonary disease that keeps them in bed for three consecutive days or more and who are thus at high risk of developing DVT or pulmonary embolism (PE). In this study, 192 high-risk patients, aged forty to ninety-two, received 125I fibrinogen and had daily radioactive scans, venous Doppler, and strain gauge plethysmography. Four preventive methods were used until patients became ambulatory: graded compression stockings (GCS) in 39, elastic bandages (EB) in 33, subcutaneous administration of 5,000 USP units of heparin (HEP) bid in 39, and oral administration of 0.5 g of acetylsalicyclic acid (ASA) bid in 35. Results were compared with those in 46 patients in a control group (CG). Twelve patients in CG, none in GCS, 4 in EB, 1 in HEP, and 2 in ASA developed DVT proved by contrast venography. There was a statistically significant difference between GCS and CG (P less than 0.0003), HEP and CG (P less than 0.0022), and ASA and CG (P less than 0.0148) but not between EB and CG (P greater than 0.10); no significant differences were found between any pair of prophylaxis groups. The significant differences could not be attributed to differences in age, sex, or length of stay in bed. PE occurred in 3 patients in CG and 1 in EB. Hemorrhagic complications occurred in 7 patients in HEP and 4 in ASA, requiring exclusion of 2 patients and 1 patient, respectively, from the study.(ABSTRACT TRUNCATED AT 250 WORDS)
Ibarra-Pérez et al. (Wed,) conducted a cohort in Pulmonary disease requiring bed rest (n=192). Graded compression stockings, heparin, or acetylsalicylic acid vs. Control group was evaluated on Deep venous thrombosis (DVT) proved by contrast venography (p=<0.0003). Graded compression stockings (0%), heparin (2.6%), and aspirin (5.7%) significantly reduced DVT compared to control (26.1%) in high-risk pulmonary patients, whereas elastic bandages did not.