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June 1, 1988Angiology

Prevalence and Prevention of Deep Venous Thrombosis of the Lower Extremities in High-Risk Pulmonary Patients

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Key result

Graded compression stockings (0%), heparin (2.6%), and aspirin (5.7%) significantly reduced DVT compared to control (26.1%) in high-risk pulmonary patients, whereas elastic bandages did not.

Why the study?

Do graded compression stockings, elastic bandages, heparin, or aspirin prevent deep venous thrombosis in high-risk pulmonary patients on bed rest?

Population

192 patients aged 40 to 92 with pulmonary disease requiring bed rest for 3 or more consecutive days, at high…

Comparison

Graded compression stockings, elastic bandages… vs Control group receiving no specified prophylaxis.

Design

Cohort

Follow-up

Until patients became ambulatory

Authors

CICarlos Ibarra-PérezInstituto Tecnológico de LeónELEnrique Lau‐CortésUniversidad de PanamáSCSylvia Colmenero-ZubiateMexican Social Security Institute

Discussion

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Implication

Supports DVT prophylaxis with stockings, heparin, or aspirin in high-risk bedridden pulmonary patients; leaves open need for randomized confirmation.

Study Design

Type

Cohort (n=192)

Structured PICO

Do graded compression stockings, elastic bandages, heparin, or aspirin prevent deep venous thrombosis in high-risk pulmonary patients on bed rest?

P
Population
192 patients aged 40 to 92 with pulmonary disease requiring bed rest for 3 or more consecutive days, at high risk for DVT or PE.
I
Intervention
Graded compression stockings (n=39), elastic bandages (n=33), subcutaneous heparin 5,000 USP units bid (n=39), or oral acetylsalicylic acid 0.5 g bid (n=35) until ambulatory.
C
Comparator
Control group receiving no specified prophylaxis (n=46).
O
Outcome
Deep venous thrombosis (DVT) proved by contrast venography.hard clinical

Main Result

Absolute Event Rate: 0% vs 26.1%

p-value: p=<0.0003

Graded compression stockings, subcutaneous heparin, and oral aspirin significantly reduced the incidence of DVT compared to control in high-risk pulmonary patients on bed rest, whereas elastic bandages did not.

Cite This Study

Ibarra-Pérez et al. (1988) conducted a cohort in Pulmonary disease requiring bed rest (n=192). Graded compression stockings, heparin, or acetylsalicylic acid vs. Control group was evaluated on Deep venous thrombosis (DVT) proved by contrast venography (p=<0.0003). Graded compression stockings (0%), heparin (2.6%), and aspirin (5.7%) significantly reduced DVT compared to control (26.1%) in high-risk pulmonary patients, whereas elastic bandages did not.

synapsesocial.com/papers/6a0a587dfdd00ab7863dcc61https://doi.org/10.1177/000331978803900603

Topics

Pulmonary embolism
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