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July 1, 1980British journal of surgery

Low dose heparin and compression stockings in the prevention of postoperative deep venous thrombosis

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Key result

Graduated compression stockings combined with low dose heparin significantly reduced postoperative DVT compared to low dose heparin alone (4.08% vs 12.24%; P<0.004).

Why the study?

Does the addition of graduated compression stockings to low dose heparin reduce the frequency of postoperative deep venous thrombosis in patients undergoing major abdominal surgery?

Population

n=98 patients undergoing major abdominal surgery

Comparison

Graduated compression stocking applied to one… vs Control leg receiving only systemic low dose…

Design

RCT, Graduated compression stocking randomly allocated to one of the legs

Follow-up

5-7 days

Authors

STS TörngrenKarolinska Institutet

Discussion

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Implication

May support adding stockings to heparin prophylaxis in abdominal surgery; leaves open confirmation in larger trials.

Study Design

Type

RCT (n=98)

Randomization

randomly allocated

Structured PICO

Does the addition of graduated compression stockings to low dose heparin reduce the frequency of postoperative deep venous thrombosis in patients undergoing major abdominal surgery?

P
Population
98 patients undergoing major abdominal surgery receiving low dose heparin prophylaxis for 5-7 days.
I
Intervention
Graduated compression stocking applied to one leg, in addition to systemic low dose heparin prophylaxis (5000 i.u. every 12 h for 5-7 days)
C
Comparator
Control leg receiving only systemic low dose heparin prophylaxis (5000 i.u. every 12 h for 5-7 days) without a compression stocking
O
Outcome
Frequency of deep venous thrombosis (DVT) diagnosed by the 125I-fibrinogen methodhard clinical

Main Result

Absolute Event Rate: 4.08% vs 12.24%

p-value: p=< 0.004

The combination of graduated compression stockings and low dose heparin significantly reduces the frequency of postoperative DVT compared to heparin alone in patients undergoing major abdominal surgery.

Cite This Study

S Törngren (1980) conducted an RCT in postoperative deep venous thrombosis (n=98). Graduated compression stocking vs. Control leg (no stocking) was evaluated on Deep venous thrombosis (DVT) (p=< 0.004). Graduated compression stockings combined with low dose heparin significantly reduced postoperative DVT compared to low dose heparin alone (4.08% vs 12.24%; P<0.004).

synapsesocial.com/papers/6a6d30efac440176ef26ff70https://doi.org/10.1002/bjs.1800670710
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1125I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography1968 · 309 citations
  2. 2Type of Compression for Reducing Venous Stasis1975 · 215 citations