Cation Sampling Enables Regiodivergent Distal Functionalization of Ketones

Key Points

• This research aims to explore the functionalization of ketones using cation sampling techniques.
• Utilized cation sampling to introduce C-heteroatom bonds in challenging positions.
• Conducted detailed mechanistic studies to understand the reaction pathway.
• Engaged with oxocarbenium species to control regioselectivity.
• Demonstrates new access to products previously unattainable through metal-based methods.
• Supports the engagement of two key oxocarbenium species for regioselective outcomes.