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May 18, 2026Journal of the American Chemical SocietyOpen Access

Cation Sampling Enables Regiodivergent Distal Functionalization of Ketones

Philipp Spieß Miloš Vavrík Jakob Frey Uroš Vezonik Daniel Kaiser Nuno Maulide

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Key Points

This research aims to explore the functionalization of ketones using cation sampling techniques.
Utilized cation sampling to introduce C-heteroatom bonds in challenging positions.
Conducted detailed mechanistic studies to understand the reaction pathway.
Engaged with oxocarbenium species to control regioselectivity.
Demonstrates new access to products previously unattainable through metal-based methods.
Supports the engagement of two key oxocarbenium species for regioselective outcomes.

Implication

Experimental study reveals new functionalization techniques for ketones, suggesting innovative synthetic pathways.

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Cite This Study

Spieß et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fa9f03e14405aa9b094 https://doi.org/10.1021/jacs.6c05299

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