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July 15, 2025

Remote-Markovnikov Hydrobromination and Hydrochlorination of Allyl Carboxylates via Dual Photoredox/Cobalt Catalysis

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Authors

AKArman KhosraviYZYuxin ZhangGZGaoyuan Zhao

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Overview

Dual cobalt and photoredox catalysis enables selective 1,3-hydrobromination in allyl carboxylates, suggesting new pathways for alkene transformations.

Key Points

  • The method enables remote-Markovnikov-selective 1,3-hydrobromination of allyl carboxylates.
  • It features a cobalt/photoredox catalytic platform that operates effectively under mild conditions.
  • Mechanistic studies support a radical relay sequence, diverging from classical methods of regioselectivity.
  • This approach enhances synthetic methods for C–X bond formation, expanding tools for hydrofunctionalization.

Cite This Study

Khosravi et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc701https://doi.org/10.26434/chemrxiv-2025-2nrb8-v2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dual Photoredox/Cobalt Catalysis Enabled Regiospecific Markovnikov Hydroboration of Unactivated Mono-, Di-, and Trisubstituted Alkenes2026
  2. 2Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables <i>Remote</i> ‐Markovnikov Hydroamination of Alkenes2026
  3. 3Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables <i>Remote</i> ‐Markovnikov Hydroamination of Alkenes2026
  4. 4Markovnikov-Selective Hydroboration of Unactivated Alkenes via MHAT under Cobalt/Photoredox Dual Catalysis2026
  5. 5Cobalt‐Catalyzed Intramolecular Markovnikov Hydrocarbonylation of Unactivated Alkenes via Hydrogen Atom Transfer2024 · 21 citations