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June 26, 2026Nature CommunicationsOpen Access

Dual Photoredox/Cobalt Catalysis Enabled Regiospecific Markovnikov Hydroboration of Unactivated Mono-, Di-, and Trisubstituted Alkenes

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Authors

XXXinyu XuHLHongchao LiuYCYiliang Chen

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Overview

Randomized trial demonstrates effective Markovnikov hydroboration in unactivated alkenes, suggesting a new synthetic approach.

Key Points

  • The study aims to develop a general method for the regiospecific Markovnikov hydroboration of unactivated alkenes.
  • Utilized dual photoredox and cobalt catalysis for the hydroboration reaction.
  • Employed photoinduced metal-hydride hydrogen atom transfer followed by radical borylation.
  • Operated under mild reaction conditions with broad substrate scope.
  • Achieved high Markovnikov selectivity in hydroboration of mono-, di-, and trisubstituted alkenes.
  • Enabled the application of this method to complex substrates from natural products.
  • Supported by density functional theory calculations and control experiments.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a3e170a030ad1a9b30909bdhttps://doi.org/10.1038/s41467-026-74638-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Markovnikov-Selective Hydroboration of Unactivated Alkenes via MHAT under Cobalt/Photoredox Dual Catalysis2026
  2. 2Remote-Markovnikov Hydrobromination and Hydrochlorination of Allyl Carboxylates via Dual Photoredox/Cobalt Catalysis2025
  3. 3Cobalt‐Catalyzed Intramolecular Markovnikov Hydrocarbonylation of Unactivated Alkenes via Hydrogen Atom Transfer2024 · 21 citations
  4. 4Cobalt‐Catalyzed Intramolecular Markovnikov Hydrocarbonylation of Unactivated Alkenes via Hydrogen Atom Transfer2024 · 1 citations
  5. 5Phenoxyiminato Cobalt(II) complexes in hydroboration of terminal and internal alkenes2026 · 1 citations