Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026Angewandte ChemieOpen Access

Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote ‐Markovnikov Hydroamination of Alkenes

View Full Paper
Ask AI
Bookmark
Share

Authors

AKArman KhosraviHYH. YuenSFSeth Fremin

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates regioselective C─N bond formation in amino alcohols, highlighting a novel synthetic approach.

Key Points

  • The study aims to develop a method for regioselective remote C─N bond formation using alkenes, expanding the synthesis of amino alcohols.
  • Utilized cooperative photoredox, cobalt, and Brønsted acid catalysis.
  • Investigated metal–hydride hydrogen atom transfer (MHAT) and radical acyloxy migration mechanisms.
  • Conducted experimental and computational studies to elucidate reaction pathways.
  • Achieved regioselective 1,3-hydroamination of allyl carboxylates with a broad substrate scope.
  • Demonstrated formation of protected tertiary alkyl amino alcohols with secondary variants accessible.
  • Confirmed radical ligand transfer at a Co(III)─N intermediate as the mechanism for C─N bond formation.

Cite This Study

Khosravi et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6871aea7db3c1953f91dhttps://doi.org/10.1002/ange.8746225
View Full Paper
Ask AI
Bookmark
Share