Hypoxia Active Cyclometalated Ir(III) Nile Red Triplet Photosensitisers

Key Points

• This research focuses on evaluating the effectiveness of cyclometalated Ir(III) compounds as photosensitisers in generating singlet oxygen for photodynamic therapy.
• Utilized cyclometalated Ir(III) compounds as photosensitisers.
• Examined the generation of singlet oxygen under light activation conditions.
• Assessed therapeutic effects in vitro.
• Significantly enhanced singlet oxygen production observed using Ir(III) compounds compared to standard photosensitisers.
• Ir(III) compounds demonstrated effective photodynamic therapy results against targeted cells.
• Potential applications in hypoxic tumor environments indicated by increased reaction rates.