Hypoxia Active Cyclometalated Ir(III) Nile Red Triplet Photosensitisers

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Cyclometalated Ir(III) Nile Red complexes function as effective triplet photosensitizers for photodynamic therapy under hypoxic conditions. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Judit Fodor; Oriol Careta; Amani B. Al Riyami; John Colleran; Xiao Xiao; Sylvia M. Draper; Olga Mazuryk; Claire Condon; Carme Nogués; Jianzhang Zhao

doi:10.1039/d6qi00188b

January 1, 2026Inorganic Chemistry FrontiersOpen Access

Hypoxia Active Cyclometalated Ir(III) Nile Red Triplet Photosensitisers

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Key Points

This research focuses on evaluating the effectiveness of cyclometalated Ir(III) compounds as photosensitisers in generating singlet oxygen for photodynamic therapy.
Utilized cyclometalated Ir(III) compounds as photosensitisers.
Examined the generation of singlet oxygen under light activation conditions.
Assessed therapeutic effects in vitro.
Significantly enhanced singlet oxygen production observed using Ir(III) compounds compared to standard photosensitisers.
Ir(III) compounds demonstrated effective photodynamic therapy results against targeted cells.
Potential applications in hypoxic tumor environments indicated by increased reaction rates.

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Abstract

Cyclometalated Ir(III) compounds have gained increasing attention as promising photosensitisers for photodynamic therapy (PDT). Most photosensitisers exert their therapeutic effect by generating singlet oxygen through a light-activated reaction with molecular...

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Fodor et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fd2f03e14405aa9b45f https://doi.org/10.1039/d6qi00188b

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Hypoxia Active Cyclometalated Ir(III) Nile Red Triplet Photosensitisers

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Hypoxia Active Cyclometalated Ir(III) Nile Red Triplet Photosensitisers

Key Points

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Abstract

Discussion

Cite This Study

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