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This review aims to investigate advanced cyclometalated iridium(III) complexes designed for precision in photodynamic therapy (PDT).

June 17, 2026Metallomics

Smart Cyclometalated Iridium Photosensitizers: Stimuli-Responsive and Theranostic Systems for Precision Phototherapy

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Review explores stimuli-responsive iridium systems achieving anticancer effects in dynamic tumour environments, improving therapeutic outcomes.

This review aims to investigate advanced cyclometalated iridium(III) complexes designed for precision in photodynamic therapy (PDT).
Discussed molecular design principles for iridium(III) complexes.
Explored mechanisms of TME-, redox-, enzyme-, and light-triggered activation.
Analyzed multi-stimuli architectures enhancing robustness of photosensitizers.
Iridium(III) complexes showed improved selectivity and reduced systemic toxicity in PDT.
Enhanced therapeutic precision was achieved through real-time monitoring and imaging capabilities.
The mechanisms of activation correlated with biological outcomes, highlighting potential for future designs.

Ghosh et al. (2026) studied this question.

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Review explores stimuli-responsive iridium systems achieving anticancer effects in dynamic tumour environments, improving therapeutic outcomes.