Achieving red-light anticancer photodynamic therapy under hypoxia using Ir( iii )–COUPY conjugates

Enrique Ortega; Anna Rovira; Pezhman Ashoo; E. Izquierdo; Cormac Hally; Diego Abad-Montero; Gloria Vigueras; Alba Deyà; José L. Hernández; Jorge Galino; Manel Bosch; Marta E. Alberto; Antonio Francés‐Monerris; Santi Nonell; José Ruiz; Vicente Marchán

doi:10.1039/d4qi03369h

January 1, 2025Inorganic Chemistry FrontiersOpen Access

Achieving red-light anticancer photodynamic therapy under hypoxia using Ir( iii )–COUPY conjugates

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Key Points

To develop red-light-activated photosensitizers capable of executing effective anticancer photodynamic therapy in oxygen-depleted hypoxic environments.
Conjugated COUPY dyes to cyclometalated iridium(III) complexes to engineer red-light-absorbing hybrid photosensitizers.
Evaluated the photochemical reactivity and performance of the conjugates under hypoxic conditions typical of solid tumors.
Demonstrated that Ir(III)–COUPY conjugates activate under red light and sustain photosensitizing activity under severe hypoxia.
Confirmed the potential of Ir(III)–COUPY platforms to bypass the oxygen dependency that limits conventional anticancer photodynamic therapy.

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Implication

Preclinical study reveals red-light photodynamic anticancer activity under hypoxia using iridium-COUPY conjugates, highlighting potential treatments for oxygen-deprived tumors.

Abstract

Conjugation of COUPY dyes to cyclometalated Ir( iii ) complexes is a strategy at the frontier of the development of red-light-activated photosensitizers capable of operating under challenging hypoxic conditions, showing the promise of anticancer PDT.

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Ortega et al. (2025) studied this question.

synapsesocial.com/papers/6aa63a5424014aaf7fdd57ed https://doi.org/10.1039/d4qi03369h

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Achieving red-light anticancer photodynamic therapy under hypoxia using Ir( iii )–COUPY conjugates

Key Points

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Abstract

Discussion

Cite This Study

Achieving red-light anticancer photodynamic therapy under hypoxia using Ir( iii )–COUPY conjugates

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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