Iridium( iii ) complexes with five-membered heterocyclic ligands for combined photodynamic therapy and photoactivated chemotherapy

This is the authors' abstract. We don't add key points for this paper.

) upon visible light irradiation. Notably, Ir1 displays a high phototoxicity index of 61.7 against human cancer cells. Further studies show that light-mediated anticancer properties exerted by Ir1-Ir3 occur through reactive oxygen species (ROS) generation, caspase activation, and eventually apoptosis induction. Our study demonstrates that these complexes can act as novel dual-mode light-mediated anticancer agents.