Myocyte diameter and interstitial fibrosis strongly correlated with changes in wall motion score index (r=-0.667, p<0.001 and r=-0.567, p=0.004) during high-dose dobutamine stress echocardiography.
Observational (n=24)
Does the degree of histological disruption correlate with contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy?
In patients with idiopathic dilated cardiomyopathy, contractile reserve assessed by high-dose dobutamine stress echocardiography correlates strongly with the degree of histological disruption, specifically myocyte diameter and interstitial fibrosis.
Effect estimate: r=-0.667
p-value: p=<0.001
BACKGROUND: This study was designed to determine the relationship between histomorphometric features and contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy. METHODS: Twenty-four consecutive patients (21 men, aged 43.4+/-8.7 years) with idiopathic dilated cardiomyopathy underwent dobutamine stress echocardiography. Wall motion score index, ejection fraction, cardiac power output and end-systolic pressure/volume ratio were used as indices of left ventricular contractility. Left ventricular endomyocardial biopsy specimens (3-5 per patient) were routinely processed and stained with Masson trichrome, interstitial fibrosis and myocyte diameter were calculated quantitatively. RESULTS: Myocyte diameter and interstitial fibrosis showed strongest correlation with change in wall motion score index (r=-0.667, p<0.001, and r=-0.567, p=0.004, respectively), followed by change in ejection fraction (r=-0.603, p=0.002, and r=-0.467, p=0.021, respectively). Interstitial fibrosis showed no correlation with change of cardiac power output and end-systolic pressure/volume ratio, whereas myocyte diameter was associated with change of both indices (r=-0.565, p=0.004, and r=-0.455, p=0.025). CONCLUSIONS: Contractile reserve elicited by high-dose dobutamine is strongly related to the degree of histological disruption in patients with idiopathic dilated cardiomyopathy.
Otašević et al. (Thu,) conducted a observational in Idiopathic dilated cardiomyopathy (n=24). High-dose dobutamine stress echocardiography was evaluated on Correlation between histomorphometric features (myocyte diameter, interstitial fibrosis) and contractile reserve (change in wall motion score index) (r=-0.667, p=<0.001). Myocyte diameter and interstitial fibrosis strongly correlated with changes in wall motion score index (r=-0.667, p<0.001 and r=-0.567, p=0.004) during high-dose dobutamine stress echocardiography.