Key result
Myocyte diameter and interstitial fibrosis strongly correlated with changes in wall motion score index (r=-0.667, p<0.001 and r=-0.567, p=0.004) during high-dose dobutamine stress echocardiography.
Why the study?
Does the degree of histological disruption correlate with contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy?
Observational (n=24)
Does the degree of histological disruption correlate with contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy?
Effect estimate: r=-0.667
p-value: p=<0.001
In patients with idiopathic dilated cardiomyopathy, contractile reserve assessed by high-dose dobutamine stress echocardiography correlates strongly with the degree of histological disruption, specifically myocyte diameter and interstitial fibrosis.
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Links myocardial histology to contractile reserve on dobutamine echo in dilated cardiomyopathy; hypothesis-generating and requires prospective validation.
Otašević et al. (2004) conducted an observational in Idiopathic dilated cardiomyopathy (n=24). High-dose dobutamine stress echocardiography was evaluated on Correlation between histomorphometric features (myocyte diameter, interstitial fibrosis) and contractile reserve (change in wall motion score index) (r=-0.667, p=<0.001). Myocyte diameter and interstitial fibrosis strongly correlated with changes in wall motion score index (r=-0.667, p<0.001 and r=-0.567, p=0.004) during high-dose dobutamine stress echocardiography.
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