What is the clinical evidence from this study?

Study design: Cohort. Population: Acute myocardial infarction (n=862). Intervention: Female gender vs. Male gender. Primary outcome: 5-year mortality rate (p=<0.001).

What does this research mean for the field?

Female gender is associated with a higher unadjusted 5-year mortality rate after acute myocardial infarction compared to men, but it is not an independent predictor of mortality after adjusting for confounding factors such as age and prior cardiovascular disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1996Open Access

Influence of gender on survival, mode of death, reinfarction, use of medication, and aspects of well being during a period of five years after onset of acute myocardial infarction

Q: What are the key findings of this study?

Female gender was associated with a higher unadjusted 5-year mortality rate after AMI compared to men (61% vs 48%, p<0.001), but was not an independent predictor after adjusting for confounders.

Q: What does this research mean for the field?

Female gender is associated with a higher unadjusted 5-year mortality rate after acute myocardial infarction compared to men, but it is not an independent predictor of mortality after adjusting for confounding factors such as age and prior cardiovascular disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Key Result

Female gender was associated with a higher unadjusted 5-year mortality rate after AMI compared to men (61% vs 48%, p<0.001), but was not an independent predictor after adjusting for confounders.

Study Design

Type

Cohort (n=862)

Multicenter

Structured PICO

Does female gender independently influence 5-year mortality and prognosis after acute myocardial infarction compared to male gender?

Population

862 patients hospitalized due to acute myocardial infarction (AMI), including 581 men (67%) and 281 women (33%)

Intervention

Female gender

Comparator

Male gender

Outcome

5-year mortality ratehard clinical

Although women have a higher crude 5-year mortality after acute myocardial infarction than men, this difference is driven by age and baseline cardiovascular comorbidities rather than female gender being an independent risk factor.

Main Result

Absolute Event Rate: 61% vs 48%

p-value: p=<0.001

Abstract

BACKGROUND AND HYPOTHESIS: This study was undertaken to describe prognosis during a period of 5 years after an acute myocardial infarction (AMI) in relation to gender. METHODS: All patients studied were hospitalized in a single hospital during a period of 21 months due to AMI, regardless of age and whether they were admitted to the coronary care unit or another ward. A total of 862 AMI patients 581 (67%) men and 281 (33%) women were prospectively evaluated. Males were younger and less frequently had a history of congestive heart failure and hypertension. RESULTS: The overall 5-year mortality rate was 48% among men compared with 61% among women (p 0.2). CONCLUSION: During 5 years of follow-up in a consecutive series of 862 AMI patients, women had a worse prognosis than men, with a mortality of 61% compared with 48% (p < 0.001). However, after controlling for a number of potentially confounding prognostic factors, female gender was not independently associated with mortality.

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Cite This Study

Herlitz et al. (Mon,) conducted a cohort in Acute myocardial infarction (n=862). Female gender vs. Male gender was evaluated on 5-year mortality rate (p=<0.001). Female gender was associated with a higher unadjusted 5-year mortality rate after AMI compared to men (61% vs 48%, p<0.001), but was not an independent predictor after adjusting for confounders.

synapsesocial.com/papers/6a170dff25571367076bee52 https://doi.org/https://doi.org/10.1002/clc.4960190707

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