Monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) predict a non-dipping blood pressure pattern in hypertensive patients with stable CAD (P<0.001).
Cross-Sectional (n=80)
No
Do NLR, MLR, and PLR predict a non-dipping blood pressure pattern in hypertensive patients with stable CAD?
MLR and PLR are easily accessible and inexpensive biomarkers that can predict a non-dipping blood pressure pattern in hypertensive patients with stable coronary artery disease.
p-value: p=< 0.001
INTRODUCTION: Chronic inflammation plays an essential role in the pathophysiology of both arterial hypertension (HTN) and coronary artery disease (CAD), and is more pronounced in individuals with a non-dipper circadian blood pressure (BP) pattern. A non-dipping BP pattern is in turn is associated with increased cardiovascular morbi-mortality, and a higher risk of atherosclerotic events. Neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) are readily available predictors of systemic inflammation and cardiovascular risk. The purpose of our study is to evaluate whether NLR, MLR and PLR can be used as cost-effective predictors of a non-dipping blood pressure pattern in hypertensive patients with stable CAD. MATERIALS AND METHODS: We performed a cross-sectional retrospective analysis that included 80 patients with hypertension and stable CAD (mean age 55.51 ± 11.83 years, 71.3% male) referred to a cardiovascular rehabilitation center. All patients underwent clinical examination, 24 h ambulatory blood pressure monitoring (ABPM) and standard blood analysis. RESULTS: < 0.001) compared to dippers. CONCLUSION: Our results suggest that MLR and PLR are inexpensive and easily accessible biomarkers that predict a non-dipping pattern in hypertensive patients with stable CAD.
Drugescu et al. (Sat,) conducted a cross-sectional in Hypertension and stable coronary artery disease (n=80). Biomarkers (NLR, MLR, PLR) was evaluated on Non-dipping blood pressure pattern (p=< 0.001). Monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) predict a non-dipping blood pressure pattern in hypertensive patients with stable CAD (P<0.001).