Key result
Elevated MLR and PLR are linked to non-dipping blood pressure in hypertensive stable CAD.
Why the study?
Chronic inflammation is more pronounced in patients with a non-dipper blood pressure pattern, but whether readily available inflammatory biomarkers can predict this pattern in hypertensive patients with stable CAD is unclear.
Do elevated MLR and PLR predict a non-dipping blood pressure pattern in hypertensive patients with stable CAD?
Cross-Sectional (n=80)
No
Do elevated MLR and PLR predict a non-dipping blood pressure pattern in hypertensive patients with stable CAD?
Answers are grounded in this paper and cite their sources.
MLR and PLR are inexpensive, easily accessible biomarkers that independently predict a non-dipping blood pressure pattern in hypertensive patients with stable CAD.
INTRODUCTION: Chronic inflammation plays an essential role in the pathophysiology of both arterial hypertension (HTN) and coronary artery disease (CAD), and is more pronounced in individuals with a non-dipper circadian blood pressure (BP) pattern. A non-dipping BP pattern is in turn is associated with increased cardiovascular morbi-mortality, and a higher risk of atherosclerotic events. Neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) are readily available predictors of systemic inflammation and cardiovascular risk. The purpose of our study is to evaluate whether NLR, MLR and PLR can be used as cost-effective predictors of a non-dipping blood pressure pattern in hypertensive patients with stable CAD. MATERIALS AND METHODS: We performed a cross-sectional retrospective analysis that included 80 patients with hypertension and stable CAD (mean age 55.51 ± 11.83 years, 71.3% male) referred to a cardiovascular rehabilitation center. All patients underwent clinical examination, 24 h ambulatory blood pressure monitoring (ABPM) and standard blood analysis. CONCLUSION: Our results suggest that MLR and PLR are inexpensive and easily accessible biomarkers that predict a non-dipping pattern in hypertensive patients with stable CAD.
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Drugescu et al. (2023) conducted a cross-sectional in Hypertension and stable coronary artery disease (n=80). Elevated monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) vs. Lower MLR and PLR was evaluated on Non-dipping blood pressure pattern (p=<0.001). Elevated monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) are significantly associated with a non-dipping blood pressure pattern in hypertensive patients with stable CAD (p<0.001).
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