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March 19, 2010Clinical Chemistry and Laboratory Medicine (CCLM)

A methodological reappraisal of total and high molecular weight adiponectin determination in human peripheral circulation: comparison of four immunometric assays

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Population

102 cardiac patients and 40 healthy subjects

Comparison

Measurement of total and high molecular weight… vs Comparison among the four assays

Design

Other

Authors

CCChiara CaselliOMOmbretta MelaiuMMMaristella Maltinti

Discussion

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Overview

Assay selection may influence adiponectin-cardiac associations in practice; leaves open standardization needs for reliable research use.

Structured PICO

P
Population
102 cardiac patients and 40 healthy subjects
I
Intervention
Measurement of total and high molecular weight adiponectin using four different ELISAs (LINCO, B-Bridge, SPIbio and ALPCO)
C
Comparator
Comparison among the four assays
O
Outcome
Analytical performance and correlation between the four ELISAssurrogate

Different commercially available ELISAs for adiponectin show strong correlation but have methodological differences, with the LINCO assay showing better association with cardiac disease.

Cite This Study

Caselli et al. (2010) studied this question.

synapsesocial.com/papers/6a1aa1c34dcca2706385994chttps://doi.org/10.1515/cclm.2010.104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Immunoassays for the Selective Measurement of Human High–Molecular Weight Adiponectin2009 · 11 citations
  2. 2Total and High–Molecular Weight Adiponectin in Relation to Metabolic Variables at Baseline and in Response to an Exercise Treatment Program: Comparative Evaluation of Three Assays2007 · 8 citations
  3. 3Recent advances in the measurement of adiponectin isoform distribution2007 · 62 citations
  4. 4Total and high molecular weight adiponectin in patients with coronary artery disease2009 · 16 citations
  5. 5Total and High–Molecular Weight Adiponectin in Relation to Metabolic Variables at Baseline and in Response to an Exercise Treatment Program: Comparative Evaluation of Three Assays2007 · 12 citations