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April 1, 2009Journal of Cardiovascular Medicine

Total and high molecular weight adiponectin in patients with coronary artery disease

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Why the study?

Are levels of high molecular weight (HMW) adiponectin associated with the presence and severity of coronary artery disease?

Population

134 patients; 57 with acute coronary syndrome (ACS), 44 with stable angina, and 33 healthy patients.

Comparison

Measurement of total and high molecular weight… vs Healthy controls; internal comparisons between…

Design

Cross-sectional

Authors

AEAyman El‐MenyarNRNasser RizkANAbdulrahman D Al Nabti

Discussion

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Overview

HMW adiponectin may mark CAD presence; cross-sectional data leave open its biomarker utility pending prospective validation.

Structured PICO

Are levels of high molecular weight (HMW) adiponectin associated with the presence and severity of coronary artery disease?

P
Population
134 patients; 57 with acute coronary syndrome (ACS), 44 with stable angina, and 33 healthy patients.
I
Intervention
Measurement of total and high molecular weight (HMW) adiponectin from peripheral veins and coronary ostia.
C
Comparator
Healthy controls; internal comparisons between ACS vs. stable angina, and diabetic vs. non-diabetic CAD patients.
O
Outcome
Levels of total and HMW adiponectin in coronary ostia and peripheral veins.surrogate

High molecular weight (HMW) adiponectin may serve as a more sensitive biomarker for coronary artery disease than total adiponectin, with particularly low levels observed in diabetic patients.

Cite This Study

El‐Menyar et al. (2009) studied this question.

synapsesocial.com/papers/6a7e952cb06e944a47338f58https://doi.org/10.2459/jcm.0b013e3283252b50
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