Key result
In male patients with coronary artery disease, high-molecular weight adiponectin levels strongly correlated with total adiponectin levels (r=0.914) and were equally useful in assessing metabolic risk.
Cross-Sectional (n=186)
Yes
Effect estimate: r=0.914
p-value: p=<0.0001
Measurement of total and HMW adiponectin are equally useful in assessing metabolic risk in male patients with coronary artery disease, as changes in the HMW isoform reflect changes in total adiponectin.
Total and HMW adiponectin appear interchangeable for metabolic risk assessment in male CAD; leaves open prospective validation and generalizability.
BACKGROUND: It has been reported previously that the measurement of plasma total adiponectin level is clinically useful to estimate the risk of coronary artery disease (CAD). Here, the relevance of high molecular weight (HMW) adiponectin with risk factors for atherosclerosis is investigated METHODS AND RESULTS: A total of 186 consecutive male CAD patients participated in the study and were categorized into quartiles based on their total adiponectin level. The interquartile cut-off points were 4.0, 5.5 and 7.0 microg/ml. The HMW adiponectin levels were significantly lower in the quartile of lower total adiponectin levels both in non-diabetic and diabetic patients. In contrast, low molecular weight adiponectin levels (which were calculated as the Total - HMW) were constant. In univariate analysis, total adiponectin correlated negatively with body mass index and hemoglobin (Hb) A1c, and HMW adiponectin correlated negatively with HbA1c in non-diabetic patients. On the other hand, total and HMW adiponectin correlated positively with high-density lipoprotein-cholesterol (HDL-C) in diabetic patients. Multiple regression analysis revealed that HMW adiponectin correlated negatively with HbA1c in non-diabetic patients, and total and HMW adiponectin correlated positively with HDL-C in diabetic patients. CONCLUSIONS: Change in the HMW isoform reflects a change in total adiponectin level. Measurement of total and HMW adiponectin were equally useful in assessing metabolic risk in CAD patients.
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Komura et al. (2007) conducted a cross-sectional in Coronary Artery Disease (n=186). High-molecular weight (HMW) adiponectin vs. Total adiponectin was evaluated on Correlation between total and high-molecular weight (HMW) adiponectin levels (r=0.914, p=<0.0001). In male patients with coronary artery disease, high-molecular weight adiponectin levels strongly correlated with total adiponectin levels (r=0.914) and were equally useful in assessing metabolic risk.
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