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May 27, 2006Diabetes CareOpen Access

Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome

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Key result

The high-molecular weight adiponectin ratio (HMWR) was a better predictor of insulin resistance than total adiponectin, with a significantly larger AUC (0.713 vs 0.615; P=0.0160).

Why the study?

Does the HMW adiponectin ratio improve the prediction of insulin resistance and metabolic syndrome compared to total adiponectin levels in patients admitted for diabetes treatment or coronary angiography?

Population

298 patients admitted for diabetes treatment or coronary angiography

Comparison

Measurement of HMW ratio vs Measurement of plasma total adiponectin levels

Design

Cross-sectional

Authors

KHKazuo HaraAichi Medical UniversityMHMomoko HorikoshiRIKEN Center for Integrative Medical SciencesTYToshimasa YamauchiBunkyo University

Discussion

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Implication

HMWR may outperform total adiponectin for insulin resistance prediction; leaves open its utility for metabolic syndrome screening in diabetes or CAD admissions.

Key Points

  • This research investigates the predictive utility of plasma high-molecular weight adiponectin levels in identifying insulin resistance and metabolic syndrome.
  • 298 patients were measured for high-molecular weight and total adiponectin levels using an enzyme-linked immunosorbent assay.
  • Receiver operator characteristic curves were used to evaluate the predictive ability of the HMW ratio compared to total adiponectin levels.
  • The HMW ratio had a significantly larger area under the ROC curve for predicting insulin resistance (0.713 vs. 0.615, P = 0.0160).
  • In men, the AUC for HMWR predicting metabolic syndrome was 0.806 compared to 0.730 for total adiponectin (P = 0.0025).
  • In women, the AUC for HMWR predicting metabolic syndrome was 0.743 compared to 0.637 for total adiponectin (P = 0.0458).

Study Design

Type

Observational (n=298)

Structured PICO

Does the HMW adiponectin ratio improve the prediction of insulin resistance and metabolic syndrome compared to total adiponectin levels in patients admitted for diabetes treatment or coronary angiography?

P
Population
298 patients admitted for diabetes treatment or coronary angiography
I
Intervention
Measurement of HMW ratio (HMWR; ratio of plasma level of high-molecular weight adiponectin to total adiponectin)
C
Comparator
Measurement of plasma total adiponectin levels
O
Outcome
Prediction of the presence of insulin resistance and metabolic syndrome (measured by Area Under the ROC Curve)surrogate

Main Result

Absolute Event Rate: 0.713% vs 0.615%

p-value: p=0.0160

The ratio of high-molecular weight to total adiponectin is a superior biomarker compared to total adiponectin alone for identifying insulin resistance and metabolic syndrome.

Cite This Study

Hara et al. (2006) conducted an observational in Diabetes or coronary artery disease (n=298). High-molecular weight adiponectin ratio (HMWR) vs. Plasma total adiponectin was evaluated on Prediction of insulin resistance (AUC) (95% CI 0.620-0.805, p=0.0160). The high-molecular weight adiponectin ratio (HMWR) was a better predictor of insulin resistance than total adiponectin, with a significantly larger AUC (0.713 vs 0.615; P=0.0160).

synapsesocial.com/papers/6a1749d351b167d07f5dfbe0https://doi.org/10.2337/dc05-1801
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