Key result
Higher total adiponectin is linked to ~40% lower risk of insulin resistance.
Why the study?
Reduction of adiponectin is associated with obesity-related disorders including insulin resistance, but its predictive value for insulin resistance in metabolically healthy and diabetic adults was unclear.
Do higher levels of total and high-molecular-weight adiponectin predict a lower risk of insulin resistance in middle-aged European adults?
Observational (n=569)
Do higher levels of total and high-molecular-weight adiponectin predict a lower risk of insulin resistance in middle-aged European adults?
Odds Ratio: 0.598 (95% CI 0.483–0.723)
Total and high-molecular-weight adiponectin levels below specific cut-offs (4.22 mg/L and 2.75 mg/L, respectively) may predict a potential risk for the development of insulin resistance in middle-aged European adults.
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Adiponectin levels may aid IR risk stratification in middle-aged Europeans; cross-sectional data leaves predictive value and causality open.
Horáková et al. (2018) conducted an observational in Insulin resistance and Type 2 Diabetes Mellitus (n=569). Total and high-molecular-weight adiponectin levels was evaluated on Development of insulin resistance (OR 0.598, 95% CI 0.483-0.723). Increased levels of total adiponectin (OR 0.598; 95% CI 0.483-0.723) and its high-molecular-weight form (OR 0.360; 95% CI 0.242-0.511) are protective against insulin resistance.
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