August 27, 2003Diabetes Obesity and Metabolism
Plasma adiponectin in overweight, nondiabetic individuals with or without insulin resistance
Population
197 non-diabetic, overweight and obese subjects with features of the metabolic syndrome, stratified by BMI…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Sex differences and metabolic correlates of adiponectin may inform risk stratification; leaves open causal and prognostic roles in observational data.
Structured PICO
P
Population
197 non-diabetic, overweight (BMI > 25 kg/m2) and obese subjects with features of the metabolic syndrome (109 males, 88 females), stratified by BMI and insulin resistance.
O
Outcome
Relationship between plasma adiponectin concentration and anthropometric, glycaemic, lipid, and inflammatory parameterssurrogate
Plasma adiponectin is inversely related to BMI and insulin resistance, and directly related to HDL-cholesterol, suggesting it serves as a molecular link between obesity, insulin resistance, and atherogenic lipoproteins.
Limitations
- Cross-sectional design cannot establish causality
- Longitudinal studies are required to verify clinical application
Cite This Study
Shand et al. (2003) studied this question.