What question did this study set out to answer?

This study aims to evaluate the impact of changing clinical guidelines for antiepileptic drug prophylaxis during supratentorial neurosurgery.

June 1, 2026Open Access

PROCON Study: Preventive Antiepileptic Treatment in Supratentorial Neurosurgery – A Retrospective Before–After Analysis of a Change in Clinical Guidelines

Key Points

This study aims to evaluate the impact of changing clinical guidelines for antiepileptic drug prophylaxis during supratentorial neurosurgery.
Conducted a retrospective before-after analysis of seizure incidence following changes in clinical guidelines.
Monitored postoperative seizure incidence and functional autonomy outcomes in patients undergoing supratentorial craniotomy.
Postoperative seizure incidence after surgery was 5.5%.
Stopping prophylactic antiepileptic drugs did not increase the seizure incidence compared to prior guidelines.
Adverse events related to antiepileptic drugs occurred in 1.5% of patients.

Abstract

• Postoperative seizure incidence after supratentorial craniotomy was 5.5%. • Stopping prophylactic antiepileptic drugs did not increase seizure incidence. • One-month functional autonomy and lifestyle outcomes were similar between groups. • Adverse events related to antiepileptic drugs occurred in 1.5% of patients.

PROCON Study: Preventive Antiepileptic Treatment in Supratentorial Neurosurgery – A Retrospective Before–After Analysis of a Change in Clinical Guidelines

Key Points

Abstract

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