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June 1, 2026Open Access

β-catenin at the crossroads of cancer and neurodevelopment

Key Points

This study aims to explore the distinct roles of β-catenin in cancer and neurodevelopmental syndromes through its genetic variations.
Analysis of β-catenin functions in physiological and pathological contexts.
Assessment of therapeutic implications based on genetic alterations of CTNNB1.
Identified distinct pathogenic genetic events in CTNNB1 that influence β-catenin's function in diseases.
Proposed antagonistic therapeutic strategies based on the differing roles of β-catenin in cancer versus neurodevelopmental disorders.

Abstract

The essential role of β-catenin/CTNNB1 in cell development highlights its therapeutic potential in cancer and neurodevelopmental syndromes. Opposing functional alterations of β-catenin in these diseases reflect distinct pathogenic genetic events in CTNNB1, leading to antagonistic therapeutic approaches. A comprehensive understanding of β-catenin functions in physiology and pathology will facilitate the implementation of β-catenin/CTNNB1-based therapies.

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β-catenin at the crossroads of cancer and neurodevelopment | Synapse

Cite This Study

Nunes‐Xavier et al. (Fri,) studied this question.

synapsesocial.com/papers/6a1d230d02fbce9130638bb6 https://doi.org/https://doi.org/10.1016/j.trecan.2026.05.001