The research investigates β-catenin's dual role in cancer and neurodevelopment, indicating a need for tailored therapies.
The essential role of β-catenin/CTNNB1 in cell development highlights its therapeutic potential in cancer and neurodevelopmental syndromes. Opposing functional alterations of β-catenin in these diseases reflect distinct pathogenic genetic events in CTNNB1, leading to antagonistic therapeutic approaches. A comprehensive understanding of β-catenin functions in physiology and pathology will facilitate the implementation of β-catenin/CTNNB1-based therapies.
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Nunes‐Xavier et al. (2026) studied this question.
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