Fatty Diacid-Modified FAP-Targeted NIR Fluorescent Probes with Modulated Pharmacokinetics for Enhanced Tumor Imaging

Key Points

• This research aims to develop fatty diacid-modified near-infrared fluorescent probes for better tumor imaging.
• Developed modified fluorescent probes targeting fibroblast activation protein (FAP) for imaging.
• Assessed pharmacokinetics to improve tumor-to-background contrast.
• Evaluated systemic clearance rates of the probes.
• The modified probes showed significant improvement in tumor imaging compared to standard probes (p=0.003).
• Tumor-to-background ratios increased by 40% with the new probes, indicating enhanced contrast.
• Systemic clearance was reduced, allowing for prolonged imaging windows.