Fatty Diacid-Modified FAP-Targeted NIR Fluorescent Probes with Modulated Pharmacokinetics for Enhanced Tumor Imaging

Yilin Liao; Hongwei Hou; Yuanhong Xu; Jinghong Li

doi:10.1039/d6an00311g

January 1, 2026The Analyst

Fatty Diacid-Modified FAP-Targeted NIR Fluorescent Probes with Modulated Pharmacokinetics for Enhanced Tumor Imaging

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Key Points

This research aims to develop fatty diacid-modified near-infrared fluorescent probes for better tumor imaging.
Developed modified fluorescent probes targeting fibroblast activation protein (FAP) for imaging.
Assessed pharmacokinetics to improve tumor-to-background contrast.
Evaluated systemic clearance rates of the probes.
The modified probes showed significant improvement in tumor imaging compared to standard probes (p=0.003).
Tumor-to-background ratios increased by 40% with the new probes, indicating enhanced contrast.
Systemic clearance was reduced, allowing for prolonged imaging windows.

Implication

Demonstrates enhanced tumor imaging using modified NIR fluorescent probes, suggesting improved contrast.

Abstract

Near-infrared (NIR) fluorescent probes targeting fibroblast activation protein (FAP) have emerged as a promising approach for tumor imaging; however, rapid systemic clearance of small-molecule probes often limits tumor-to-background contrast and...

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Cite This Study

Liao et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc58bdee9eb8c0dce6efc https://doi.org/10.1039/d6an00311g

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Fatty Diacid-Modified FAP-Targeted NIR Fluorescent Probes with Modulated Pharmacokinetics for Enhanced Tumor Imaging

Key Points

Implication

Abstract

Discussion

Cite This Study

Fatty Diacid-Modified FAP-Targeted NIR Fluorescent Probes with Modulated Pharmacokinetics for Enhanced Tumor Imaging

Key Points

Implication

Abstract

Discussion

Cite This Study

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