Heart chymase-like activity in 2K1C hypertensive hamsters increased 5.2-fold at 32 weeks compared with 16 weeks, coinciding with the appearance of cardiac fibrosis and apoptosis.
Effect estimate: 5.2-fold increase
Chronic pressure overload induces cardiac tissue remodeling. Chymase is known to regulate matrix metabolism and angiotensin II formation. In the present study, we investigated the pathophysiological functions of chymase in the pressure-overloaded hamster heart induced by a two-kidney, one-clip (2K1C) hypertension procedure. Fibrosis and apoptosis were observed in the pressure-overloaded hearts of 2K1C hamsters 32 weeks after clipping, but these histological changes were not detected at 16 weeks. Heart chymase-like activity of 2K1C hamsters at 32 weeks increased 5.2-fold compared with that at 16 weeks, while angiotensin-converting enzyme was not activated. Chymase might be involved in cardiac tissue remodeling during the chronic stage of hypertension.
Shiota et al. (Mon,) conducted a other in Hypertension and cardiac tissue remodeling. Two-kidney, one-clip (2K1C) hypertension procedure vs. 16 weeks post-clipping was evaluated on Heart chymase-like activity (5.2-fold increase). Heart chymase-like activity in 2K1C hypertensive hamsters increased 5.2-fold at 32 weeks compared with 16 weeks, coinciding with the appearance of cardiac fibrosis and apoptosis.
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