Key result
Heart chymase-like activity in 2K1C hypertensive hamsters increased 5.2-fold at 32 weeks compared with 16 weeks, coinciding with the appearance of cardiac fibrosis and apoptosis.
Why the study?
Does pressure overload from 2K1C hypertension increase chymase activity and cardiac remodeling in hamsters?
Population
Hamsters with pressure-overloaded hearts induced by a two-kidney, one-clip (2K1C) hypertension procedure
Comparison
Two-kidney, one-clip hypertension procedure vs 16 weeks post-clipping vs 32 weeks post-clipping
Design
Preclinical
Follow-up
32 weeks
Authors
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Hypothesis-generating for chymase in hypertensive remodeling; human trials needed before clinical consideration.
Does pressure overload from 2K1C hypertension increase chymase activity and cardiac remodeling in hamsters?
Effect estimate: 5.2-fold increase
Chymase activity is significantly increased during the chronic stage of hypertension in hamsters, suggesting a role in cardiac tissue remodeling and fibrosis.
Shiota et al. (1997) studied Hypertension and cardiac tissue remodeling. Two-kidney, one-clip (2K1C) hypertension procedure vs. 16 weeks post-clipping was evaluated on Heart chymase-like activity (5.2-fold increase). Heart chymase-like activity in 2K1C hypertensive hamsters increased 5.2-fold at 32 weeks compared with 16 weeks, coinciding with the appearance of cardiac fibrosis and apoptosis.
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