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June 4, 2026

Protective Effects of Nigella Sativa Against Acrylamide-induced Toxicity in Submandibular Salivary Glands of Albino Rats.

Key Points

The aim is to evaluate the protective effects of Nigella Sativa against acrylamide-induced toxicity in submandibular salivary glands of rats.
Albino rats were administered acrylamide to induce toxicity in submandibular salivary glands.
Real-time polymerase chain reaction (RT-qPCR) was used to assess gene expression.
The study measured cytotoxic effects and oxidative stress levels.
Acrylamide caused significant cytotoxic effects on salivary glands (P<0.05).
Increased oxidative stress and mitochondrial dysfunction were observed as key mechanisms.
Nigella Sativa treatment effectively mitigated acrylamide's toxic effects.

Abstract

Introduction: (NS) oil against AA- induced toxicity on the submandibular salivary glands (SMGs) of Albino rats. Materials & Methods: ) expression using realtime polymerase chain reaction (RT-qPCR). Results: gene expression. The study revealed a significant cytotoxic effect of AA on SMGs of albino rats (P<0.05), presumably by the generation of oxidative stresses and mitochondrial dysfunction. Conclusion: NS effectively mitigated these toxic effects, suggesting its potential as a natural antioxidant.

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