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June 4, 20260 citations

Protective Effects of Nigella Sativa Against Acrylamide-induced Toxicity in Submandibular Salivary Glands of Albino Rats.

TATaghyan Salma AwadBritish University in EgyptMFMahmoud Elham FathySuez Canal UniversityTMTaha Rasha MohamedSuez Canal University

Key Points

  • The aim is to evaluate the protective effects of Nigella Sativa against acrylamide-induced toxicity in submandibular salivary glands of rats.
  • Albino rats were administered acrylamide to induce toxicity in submandibular salivary glands.
  • Real-time polymerase chain reaction (RT-qPCR) was used to assess gene expression.
  • The study measured cytotoxic effects and oxidative stress levels.
  • Acrylamide caused significant cytotoxic effects on salivary glands (P<0.05).
  • Increased oxidative stress and mitochondrial dysfunction were observed as key mechanisms.
  • Nigella Sativa treatment effectively mitigated acrylamide's toxic effects.

Abstract

Introduction: (NS) oil against AA- induced toxicity on the submandibular salivary glands (SMGs) of Albino rats. Materials & Methods: ) expression using realtime polymerase chain reaction (RT-qPCR). Results: gene expression. The study revealed a significant cytotoxic effect of AA on SMGs of albino rats (P<0.05), presumably by the generation of oxidative stresses and mitochondrial dysfunction. Conclusion: NS effectively mitigated these toxic effects, suggesting its potential as a natural antioxidant.

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Cite This Study

Awad et al. (2025) studied this question.

synapsesocial.com/papers/6a21164cd499ed480b16f432https://doi.org/10.32598/ari.80.5.3494
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  5. 5Hepato-Renal Protective Effects of Nigella sativa Oil in Cyclophosphamide-Induced Toxicity: Insights from Adult Wister Rat Models2024 · 1 citations