Resting muscle sympathetic nerve activity burst frequency was negatively correlated with sympathetic transduction of blood pressure (r = -0.42; P < 0.01) and transduction slope (r = -0.66; P < 0.01).
Cross-Sectional (n=107)
Incorporating MSNA burst frequency into the calculation of sympathetic transduction of blood pressure accounts for prevailing resting burst frequency, allowing for more accurate comparisons between individuals.
Effect estimate: r = -0.42
p-value: p=<0.01
Calculating the blood pressure (BP) response to a burst of muscle sympathetic nerve activity (MSNA), termed sympathetic transduction, may be influenced by an individual’s resting burst frequency. We examined the relationships between sympathetic transduction and MSNA in 107 healthy males and females and developed a normalized sympathetic transduction metric to incorporate resting MSNA. Burst-triggered signal averaging was used to calculate the peak diastolic BP response following each MSNA burst (sympathetic transduction of BP) and following incorporation of MSNA burst cluster patterns and amplitudes (sympathetic transduction slope). MSNA burst frequency was negatively correlated with sympathetic transduction of BP ( r = −0.42; P 0.22). We propose that incorporating MSNA burst frequency into the calculation of sympathetic transduction will allow comparisons between participants with varying levels of resting MSNA.
Nardone et al. (Wed,) conducted a cross-sectional in Healthy (n=107). Resting muscle sympathetic nerve activity (MSNA) burst frequency vs. Low vs high MSNA was evaluated on Correlation between MSNA burst frequency and sympathetic transduction of BP (r = -0.42, p=<0.01). Resting muscle sympathetic nerve activity burst frequency was negatively correlated with sympathetic transduction of blood pressure (r = -0.42; P < 0.01) and transduction slope (r = -0.66; P < 0.01).