Key result
Resting muscle sympathetic nerve activity burst frequency was negatively correlated with sympathetic transduction of blood pressure (r = -0.42; P < 0.01) and transduction slope (r = -0.66; P < 0.01).
Why the study?
Calculating sympathetic transduction of blood pressure may be influenced by an individual's resting muscle sympathetic nerve activity burst frequency.
Cross-Sectional (n=107)
Effect estimate: r = -0.42
p-value: p=<0.01
Incorporating MSNA burst frequency into the calculation of sympathetic transduction of blood pressure accounts for prevailing resting burst frequency, allowing for more accurate comparisons between individuals.
Higher MSNA burst frequency associates with lower BP transduction; leaves open whether burst-frequency adjustment refines autonomic phenotyping in future studies.
Calculating the blood pressure (BP) response to a burst of muscle sympathetic nerve activity (MSNA), termed sympathetic transduction, may be influenced by an individual’s resting burst frequency. We examined the relationships between sympathetic transduction and MSNA in 107 healthy males and females and developed a normalized sympathetic transduction metric to incorporate resting MSNA. Burst-triggered signal averaging was used to calculate the peak diastolic BP response following each MSNA burst (sympathetic transduction of BP) and following incorporation of MSNA burst cluster patterns and amplitudes (sympathetic transduction slope). MSNA burst frequency was negatively correlated with sympathetic transduction of BP ( r = −0.42; P < 0.01) and the sympathetic transduction slope ( r = −0.66; P < 0.01), independent of sex. MSNA burst amplitude was unrelated to sympathetic transduction of BP in males ( r = 0.04; P = 0.78), but positively correlated in females ( r = 0.44; P < 0.01) and with the sympathetic transduction slope in all participants ( r = 0.42; P < 0.01). To control for MSNA, the linear regression slope of the log-log relationship between sympathetic transduction and MSNA burst frequency was used as a correction exponent. In subanalysis of males (38 ± 10 vs. 14 ± 4 bursts/min) and females (28 ± 5 vs. 12 ± 4 bursts/min) with high versus low MSNA, sympathetic transduction of BP and sympathetic transduction slope were lower in participants with high MSNA (all P < 0.05). In contrast, normalized sympathetic transduction of BP and normalized sympathetic transduction slope were similar in males and females with high versus low MSNA (all P > 0.22). We propose that incorporating MSNA burst frequency into the calculation of sympathetic transduction will allow comparisons between participants with varying levels of resting MSNA.
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Nardone et al. (2021) conducted a cross-sectional in Healthy (n=107). Resting muscle sympathetic nerve activity (MSNA) burst frequency vs. Low vs high MSNA was evaluated on Correlation between MSNA burst frequency and sympathetic transduction of BP (r = -0.42, p=<0.01). Resting muscle sympathetic nerve activity burst frequency was negatively correlated with sympathetic transduction of blood pressure (r = -0.42; P < 0.01) and transduction slope (r = -0.66; P < 0.01).
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